Endocrine Abstracts

Background: Children receiving chemotherapy for ALL may be susceptible to fractures and avascular necrosis (AVN).Aim: To determine the incidence and risk factors for bone-related morbidity in children on ALL chemotherapy.Patients and methods: The medical records of all (n, 186, male: 122) children presenting with ALL between 1997 and 2007 and treated with ALL97/01or UKALL 2003 at one centre were studied. Bone morbidity was d...

The high dose short Synacthen (corticotropin) test (SST) is widely used to investigate suspected secondary adrenal insufficiency but concern remains about falsely reassuring results with potentially serious clinical consequences.In order to evaluate the long-term safety of the SST, we retrospectively evaluated the clinical outcome in 178 patients who achieved 30-minute cortisol values in the lowest 15th percentile of normal healthy responses. This subgro...